Ketamine Infusion Therapy in Franklin, TN

What Is Ketamine?

Ketamine is an anesthetic drug that has been safely administered by anesthesiologists since 1970. Over the past 20 years, physicians have learned that ketamine can be used to treat a variety of conditions including:

  • Major depression
  • Post-traumatic stress disorder (PTSD)
  • Anxiety and/or OCD (Obsessive Compulsive Disorder)
  • Chronic pain
  • And More

At the Tennessee Ketamine and Wellness Center, we give HOPE to patients who have not responded to other treatments for these conditions. In addition to the Nashville, TN area, patients travel from all across the country to receive care at the Tennessee Ketamine and Wellness Center.

How We Are Different

Our anesthesiologists will safely titrate your dose upwards to maximize the likelihood of a positive response using most commonly one-hour infusions for mental health indications and four-hour infusions for chronic pain or opioid dependence indications.

Many patients for whom ketamine is effective in reducing pain are able to reduce the number of pain medications they need to take, and some can entirely eliminate their dependence on opioid pain medicines.

How Does Ketamine Work?

Ketamine can work in three different ways to effectively treat pain and depression.

  • It increases the amount of glutamate in the nervous system, which is an excitatory amino acid and neurotransmitter. This increases neuro connections so that the brain and spinal cord process pain in a healthier way, which also decreases depression.
  • It resets pain receptors. With chronic pain, these receptors are turned on all the time. Ketamine quiets them down.
  • It decreases the inflammation in the nervous system that contributes to pain and depression.

Treatment Requires A Series of Visits
To The Center

Several options for ketamine administration are available at Tennessee Ketamine and Wellness Center – intravenous (IV) infusion, intramuscular (IM) injection, and nasal spray — which are both administered on-site at the center over a series of visits. In addition to Ketamine, we offer NAD infusions as well as other types of supplements to support your overall well-being.

Tennessee Ketamine Team

Our medical doctors provide ketamine infusions with safety and patient comfort as our top priority.

Every patient undergoes a comprehensive evaluation by an anesthesiologist, who closely oversees their individual care. Our team has significant experience developing highly effective ketamine infusion protocols while minimizing side effects.

Our staff provides support and comfort to patients. We fully explain each procedure so patients know what to expect. Treatment is constantly monitored by a nurse to ensure safety, and an anesthesiologist is always on-site and immediately available.

Dr. Malchow served as an anesthesiologist for 25 years in the armed forces before retiring as a colonel in 2008. He then became an associate professor at Vanderbilt University Medical Center in Nashville, where he was the first Vanderbilt physician to offer intensive ketamine infusion therapy in 2014. In 2015, he established one of the few ketamine infusion centers (KIC) in the Veteran Health Administration and the only KIC in the U.S. specifically targeting opioid cessation/reduction.

He is an acknowledged U.S. expert on ketamine administration, having presented his extensive experience with ketamine in the veteran population at the American Society of Ketamine Physicians in 2018 and has given multiple lectures regarding the use of ketamine to national audiences in 2021. Dr. Malchow has published over 20 peer-reviewed journal articles and serves regularly on worldwide medical missions supporting those in need.

Dr. Malchow is honored to serve as the Medical Director for the Tennessee Ketamine & Wellness Center to provide compassionate and competent care for those suffering from depression, PTSD, OCD, chronic pain, and opioid dependence.

Dr. Randall Malchow, M.D.
Dr. Randall Malchow, M.D.
Medical Doctor

Come & Visit

If coming South from Nashville

  1. Take I-65 South to the Cool Springs area.
  2. Take Exit 69 – Moores Lane Galleria Blvd.
  3. Bear RIGHT towards West Moores Lane.
  4. At the STOP sign, turn RIGHT on to Moores Lane.
  5. Go through the first stop light (entrance to I-65 South).
  6. Go through the second stop light (Galleria Blvd.).
  7. Turn LEFT at the third stop light (Mallory Ln.).
  8. Go through the first stop light (Seabourd Ln.).
  9. Go through the second stop light (Baker’s Bridge Ave.).
  10. Go through the third stop light (Crossroads Blvd.).
  11. Turn RIGHT at the first opportunity (the road is un-named, but you will see it just prior to our red brick office building).
  12. Turn left into the parking lot and park anywhere you like.
  13. There are entrances on opposite sides to the building.
  14. Take the elevator to the third floor and come to Suite 300.

If coming North from Franklin, TN or anywhere South of Franklin

  1. Take I-65 North to to the Cool Springs area.
  2. Take Exit 68B – West Cool Springs Blvd.
  3. At the first stop light, turn RIGHT (Mallory Ln.).
  4. Go through the first stoplight (road is not marked).
  5. Go thorough the second stop light (Mallory Station Rd./South Springs Blvd.).
  6. Go through the third stop light (Nichol Mill Rd.) – you will see a Burger King on the far left corner.
  7. Turn LEFT at the first opportunity (the road is un-named, but you will see it is just after our red brick office building on the left, just beyond Burger King).
  8. Turn left into the parking lot and park anywhere you like.
  9. There are entrances on opposite sides to the building.
  10. Take the elevator to the third floor and come to Suite 300.

1909 Mallory Lane, Suite 300
Franklin, TN 37067

ketamine infusion therapy in franklin, tn
nasal ketamine therapy in franklin tn


Find answers to your questions about Ketamine Infusion Therapy.


Getting Started

Follow these steps to get started with Ketamine Infusion Therapy.

ketamine therapy in franklin tn

Health Professionals

We can work together to provide care for your patients.