Nasal Ketamine Treatment in Franklin, TN

What Is Nasal Ketamine?

Tennessee Ketamine & Wellness Center is REMS*-certified to provide SPRAVATO™ (esketamine) CIII, a nasal spray approved for use in conjunction with an oral antidepressant in adults with treatment-resistant depression (TRD). People who are currently struggling with major depressive disorder (MDD) may have TRD if they have not responded adequately to at least two different antidepressants of adequate dose and duration in the current depressive episode.

SPRAVATO™ was approved by the U.S. Food & Drug Administration on March 5, 2019, and carries a Boxed WARNING because of the risks for sedation, dissociation, and abuse and misuse. SPRAVATO™ is only available through a restricted program called the SPRAVATO™ REMS Program and can only be administered at healthcare settings certified in the SPRAVATO™ REMS Program and to patients enrolled in the REMS Program.

*Risk Evaluation and Mitigation Strategy

Certified Treatment Center

As a certified treatment center, Tennessee Ketamine & Wellness Center medical staff have been trained to prescribe, dispense, and administer SPRAVATO™ and have established processes and procedures in accordance with the REMS Program requirements. A board-certified anesthesiologist will provide direct supervision as the patient self-administers SPRAVATO™ and will monitor every patient after every dose for at least 2 hours for resolution of sedation and dissociation time and changes in vital signs.

All patients will require transportation from Tennessee Ketamine & Wellness Center following the observation period, as they should not drive or operate machinery until the day after a treatment session, following a restful sleep.

Nasal ketamine can be administered either through the Spravato program or through generic nasal ketamine; your physician will discuss the pros and cons of each alternative.


SPRAVATO™ is a prescription medicine, used along with an oral antidepressant, for TRD in adults. SPRAVATO™ is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO™ is safe or effective as an anesthetic medicine. SPRAVATO™ is not for use in children.

What are the initial steps?

  • Discuss the SPRAVATO™ REMS Program with your doctor.
  • Have your doctor submit a referral from the Center’s website page for “Health Professionals”.
  • Call the Tennessee Ketamine & Wellness Center at (615) 813-5006 and schedule a consultation.
  • If, after evaluation, it is determined that you are a candidate for the SPRAVATO™ REMS Program, our board-certified anesthesiologist will write a prescription for SPRAVATO™ to be filled from a REMS-certified pharmacy and delivered to the Center.
  • Once SPRAVATO™ is delivered for a named patient, we will schedule your appointment within 14 days after receipt.
nasal ketamine therapy in franklin tn


Find answers to your questions about Ketamine Infusion Therapy.


Getting Started

Follow these steps to get started with Ketamine Infusion Therapy.

ketamine therapy in franklin tn

Health Professionals

We can work together to provide care for your patients.